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Guide RNAs with embedded barcodes boost CRISPR-pooled screens

Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1

Patched1-ArhGAP36-PKA-Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation

PARIS, an optogenetic method for functionally mapping gap junctions

Single-cell multiomics sequencing and analyses of human colorectal cancer

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

Unnatural cytosine bases recognized as thymines by DNA polymerases via the formation of the Watson‐Crick geometry

Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution

T-ALL leukemia stem cell `stemness` is epigenetically controlled by the master regulator SPI1

Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Genome-Wide Evolutionary Analysis of Natural History and Adaptation in the World’s Tigers

A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour

Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila

Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation

Biosynthetic energy cost for amino acids decreases in cancer evolution

An OB-fold complex controls the repair pathways for DNA double-strand breaks

Dissecting the global dynamic molecular profiles of human fetal kidney development by single-cell RNA sequencing

Genomic analyses of visual cognition: perceptual rivalry and top-down control